Checkpoint Inhibitors Side Effects

Diarrhea pneumonitis inflammation in the lungs rashes and itchiness problems with some hormone levels kidney infections.

Checkpoint inhibitors side effects.

Common side effects associated with currently approved checkpoint immunotherapies may include but are not limited to. Fatigue rash colitis infusion related reactions diarrhea asthenia arthralgias constipation decreased appetite cough dyspnea headache insomnia nausea pain including in the abdomen back and musculoskeletal system peripheral edema pneumonitis radiation pneumonitis pruritus pyrexia vomiting and weight loss. Since these drugs rev up your immune system they can cause a range of side effects including fatigue cough nausea loss of appetite rash and problems in your lungs kidneys intestines. On average symptoms appear around nine weeks after starting treatment and may include.

Mp inflammatory reactions involving the skin and the gastrointestinal tract are among the most common adverse events seen with checkpoint inhibitors. Paying careful attention to potential symptoms is therefore crucial. Occasional any grade toxicities in 5 20 of patients include fatigue headache arthralgia rash pruritus pneumonitis diarrhoea and or colitis hepatitis and endocrinopathies table 1. Fatigue weakness nausea confusion headache loss of appetite vision problems fever.

Other immune checkpoint inhibitors are under clinical evaluation. The most common side effects of checkpoint inhibitors are. Checkpoint inhibitor associated neurological side effects are rare but potentially life threatening. He says he figures these are just normal side effects of his medication.

However immune checkpoint blockade can lead to the breaking of immune self tolerance thereby inducing a novel syndrome of autoimmune autoinflammatory side effects designated as immune related adverse events mainly including rash colitis hepatitis and endocrinopathies.